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Propofol Injectable Emulsion

Propofol Injectable Emulsion

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  • Description:

    • Propofol injectable emulsion is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration.
    • The chemical name for propofol is 2,6-diisopropylphenol.
    • It is formulated as a white, oil-in-water emulsion and contains additional components such as soybean oil, glycerol, egg lecithin, and disodium edetate.
    • The emulsion is isotonic and has a pH of 7 to 8.51.
  • Pharmacology:

    • Propofol induces anesthesia rapidly, with minimal excitation, usually within 40 seconds from the start of injection (the time for one arm-brain circulation).
    • Its mechanism of action is not fully understood, but it is thought to positively modulate the inhibitory function of the neurotransmitter GABA through the ligand-gated GABAA receptors.
    • Steady-state propofol blood concentrations are generally proportional to its pharmacodynamic properties2.
  • Safety Considerations:

    • Strict aseptic technique must always be maintained during handling of propofol.
    • Propofol injectable emulsion is a single access parenteral product (single patient infusion vial) containing disodium edetate (EDTA) to inhibit the rate of microbial growth for up to 12 hours in case of accidental extrinsic contamination.
    • However, it is not an antimicrobially preserved product under USP standards, so contamination should be suspected and the product discarded if necessary.
    • Reports exist of microbial contamination due to failure to use aseptic technique, leading to serious consequences.
    • Propofol vials are never to be accessed more than once or used on more than one person1.

Remember to consult a healthcare professional for personalized advice regarding the use of Propofol Injectable Emulsion. If you have any further questions or need additional information, feel free to ask! 😊

Propofol Injectable Emulsion

  • Strengths

    1%, 2%

  • Fill Volumes

    10 ml, 20 ml, 50 ml

  • Container

    Glass Vial

  • Use

    Propofol is an intravenous anesthetic used for procedural sedation, during monitored anesthesia care, or as an induction agent for general anesthesia.

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