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Denosumab Injection

Updated: Nov 14, 2023

Denosumab Injection

Denosumab is a medication used in the treatment of certain bone-related conditions. It is a monoclonal antibody that works by inhibiting the activity of a protein called RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand). RANKL plays a crucial role in the regulation of bone remodeling, which involves the removal of old bone tissue and the formation of new bone.

Denosumab is primarily used for the following medical purposes:

  1. Osteoporosis: Denosumab is used to treat postmenopausal women with osteoporosis who are at high risk of fractures. It can also be used to treat osteoporosis in men and to increase bone mass in patients receiving certain treatments for cancer.

  2. Bone Metastases: It is used to prevent skeletal-related events (such as fractures or spinal cord compression) in patients with certain types of cancer (e.g., breast cancer, prostate cancer) that have spread to the bones.

  3. Giant Cell Tumor of Bone: Denosumab is used to treat giant cell tumor of bone that cannot be surgically removed.

  4. Hypercalcemia of Malignancy: It can be used in the management of hypercalcemia (high levels of calcium in the blood) caused by malignancies.

Denosumab is administered as an injection under the skin (subcutaneous), Denosumab Injection and is typically given by a healthcare professional. It works by blocking the activity of RANKL, which reduces the activity of bone-resorbing cells (osteoclasts) and, in turn, helps to increase bone density and strength.

As with any medication, there can be potential side effects and risks associated with Denosumab, so it's important for patients to discuss their medical history and any concerns with their healthcare provider before starting treatment. Regular monitoring and follow-up with a healthcare professional are often required during Denosumab therapy to ensure its effectiveness and safety.


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