Daptomycin for Injection
Daptomycin injection is used to treat certain blood infections or serious skin infections caused by bacteria in adults and children 1 year of age and older.
Daptomycin for Injection is a lipopeptide antibacterial medication used to treat specific infections. Let’s explore more about it:
Indications:
Complicated Skin and Skin Structure Infections (cSSSI): Daptomycin is effective in treating adult patients with complicated skin and skin structure infections.
Staphylococcus aureus Bloodstream Infections (Bacteremia): It is also indicated for treating Staphylococcus aureus bloodstream infections, including those with right-sided infective endocarditis.
Limitations of Use:
Daptomycin is not indicated for the treatment of pneumonia.
It is not recommended for left-sided infective endocarditis due to S. aureus.
Dosage and Administration:
Administer Daptomycin intravenously in 0.9% sodium chloride either by injection over a 2-minute period or by infusion over a 30-minute period.
Recommended dosage regimen for adult patients:
Creatinine Clearance (CLCR) ≥ 30 mL/min:
For complicated skin and skin structure infections (cSSSI): 4 mg/kg once every 24 hours.
For S. aureus bacteremia: 6 mg/kg once every 24 hours.
Creatinine Clearance (CLCR) < 30 mL/min, including hemodialysis and CAPD:
For both cSSSI and S. aureus bacteremia: 4 mg/kg once every 48 hours (administered following hemodialysis on hemodialysis days).
Adverse Reactions:
Common adverse reactions include diarrhea, headache, dizziness, rash, abnormal liver function tests, elevated creatine phosphokinase (CPK), urinary tract infections, hypotension, and dyspnea1.
Remember to consult your healthcare provider for personalized advice regarding the use of Daptomycin for Injection in your specific situation. 😊