Eculizumab injection is a medication belonging to a group of drugs called monoclonal antibodies. Here’s what you need to know:
Uses:
Eculizumab is used to treat two rare blood diseases:
Paroxysmal Nocturnal Hemoglobinuria (PNH): PNH is a type of anemia where red blood cells are broken down excessively in the body, leading to insufficient healthy cells to transport oxygen throughout the body.
Atypical Hemolytic Uremic Syndrome (aHUS): aHUS is a serious kidney disorder characterized by abnormal blood clotting in small blood vessels, which can lead to kidney damage.
How It Works:
Eculizumab works by blocking the activity of a part of the immune system that may damage blood cells in people with PNH and cause abnormal clot formation in people with aHUS.
Important Safety Information:
Meningococcal Infection Risk: Receiving eculizumab injection may increase the risk of developing a meningococcal infection (an infection affecting the brain and spinal cord or spreading through the bloodstream). Symptoms include headache, fever, stiff neck or back, confusion, muscle aches, and sensitivity to light.
You will need to receive a meningococcal vaccine at least 2 weeks before starting eculizumab treatment to reduce this risk.
Carry a patient safety card with information about meningococcal disease risk during and after treatment.
Even with vaccination, there is still a risk of meningococcal disease during or after eculizumab treatment.
Soliris REMS Program: Eculizumab is available only from doctors enrolled in the Soliris REMS program. This program ensures proper risk communication and vaccination.
Your doctor or pharmacist will provide you with a patient information sheet (Medication Guide) when you start eculizumab treatment.
Remember to consult your healthcare provider for personalized advice, and if you have further questions or need additional information, feel free to ask! 😊