Remifentanil Hydrochloride for injection is given to patients during surgery for pain relief and adjunctive to an anesthetic.
Remifentanil Hydrochloride for Injection. This medication is commonly used in anesthesia and pain management. Here are the key details:
Chemical Composition:
Remifentanil hydrochloride is a μ-opioid agonist.
Its chemical structure is 3-[4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino]-1-piperidine]propanoic acid methyl ester, hydrochloride salt (C20H28N2O5·HCl) with a molecular weight of 412.91.
The powder is sterile, nonpyrogenic, and preservative-free.
Administration:
Given intravenously (IV) after reconstitution and dilution.
Each vial contains 1, 2, or 5 mg of remifentanil base.
The pH of reconstituted solutions ranges from 2.5 to 3.5.
Pharmacodynamics:
Rapid onset and peak effect.
Short duration of action.
Blood-brain equilibration half-time of 1 ± 1 minute.
Effects closely follow blood concentrations.
Rapid recovery (within 5 to 10 minutes).
Hemodynamics:
Dose-dependent hypotension and bradycardia.
Hemodynamic changes are proportional to blood concentrations.
Rapid titration for desired depth of anesthesia/analgesia.
Indications:
Used during induction and maintenance of general anesthesia.
Continuation into the immediate postoperative period.
Component of monitored anesthesia care.
Remember, this information is not a substitute for professional medical advice. Consult your healthcare provider for personalized guidance. 😊🌟