Sufentanil Citrate Injection

What is Sufentanil Citrate Injection?
Sufentanil Citrate Injection is a potent, synthetic opioid analgesic belonging to the phenylpiperidine class. It is a highly specialized medication used primarily in surgical and critical care settings. As a derivative of fentanyl, it is one of the most powerful analgesics available in clinical practice, characterized by a rapid onset of action and high lipid solubility, which allows it to cross the blood-brain barrier almost instantly.
Uses of Sufentanil Citrate Injection
General Anesthesia: Used as an analgesic adjunct for the induction and maintenance of balanced general anesthesia.
Major Surgical Procedures: Specifically indicated for cardiac, orthopedic, or neurosurgical procedures where high-level pain control is required.
Epidural Analgesia: Administered into the epidural space for labor and delivery or post-operative pain management.
Critical Care Sedation: Used for analgesia in mechanically ventilated patients in the ICU.
Primary Anesthetic Agent: At very high doses, it can be used as the primary anesthetic for major surgeries, particularly those involving heart-lung bypass.
How Does Sufentanil Citrate Injection Work?
Sufentanil is a highly selective mu-opioid receptor agonist. It binds with extreme affinity to these receptors in the brain and spinal cord. By activating the mu-receptors, it inhibits the transmission of pain signals and alters the perception of pain. Its potency is approximately 5 to 10 times that of fentanyl and nearly 500 to 1,000 times that of morphine, allowing for effective pain management with very small dosages.
FAQs on Sufentanil Citrate Injection
1. How does Sufentanil compare to Fentanyl? Sufentanil is significantly more potent than fentanyl. It also has a slightly faster onset and a shorter "context-sensitive half-life" after short-term infusions, which can lead to a more predictable recovery in certain surgical scenarios.
2. Is there a risk of chest wall rigidity? Yes. Like other potent fentanyl derivatives, rapid intravenous administration of Sufentanil can cause skeletal muscle rigidity, particularly in the chest wall (often called "stiff chest syndrome"). This can make mechanical ventilation difficult and is usually managed with neuromuscular blocking agents.
3. What is the standard monitoring protocol? Because of its extreme potency and risk of respiratory depression, Sufentanil must only be administered by trained anesthesia professionals in environments where advanced airway management and resuscitation equipment (including Naloxone) are immediately available.
Therapeutic Category
Pain & Analgesics (Opioid Analgesic)
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