Palonosetron Hydrochloride Injection – Manufacturer, Exporter & Supplier

What is Palonosetron Hydrochloride Injection?
Palonosetron Hydrochloride Injection is a second-generation 5-HT3 receptor antagonist used to prevent acute and delayed nausea and vomiting associated with chemotherapy and surgical procedures. It has a longer half-life and strong receptor binding affinity, making it more effective compared to earlier 5-HT3 antagonists.
 
Uses of Palonosetron Hydrochloride Injection
• Prevention of acute chemotherapy-induced nausea and vomiting (CINV)
• Prevention of delayed CINV
• Prevention of postoperative nausea and vomiting (PONV)
• Suitable for moderately and highly emetogenic chemotherapy
• Can be used in both adult and pediatric patients (as per guidelines)
 
How Does Palonosetron Hydrochloride Injection Work?
Palonosetron works by blocking 5-HT3 receptors located in the brain and gastrointestinal tract. By preventing serotonin from binding to these receptors, it helps stop nausea and vomiting signals triggered by chemotherapy and surgery. Its long half-life (around 40 hours) ensures prolonged protection compared to other antiemetics.
 
FAQs on Palonosetron Hydrochloride Injection
1. What is Palonosetron used for?
It is used to prevent acute and delayed nausea and vomiting caused by chemotherapy and to reduce postoperative nausea and vomiting.
2. How is Palonosetron Injection administered?
It is given as a single slow intravenous bolus or IV infusion, typically 30 minutes before chemotherapy or anesthesia.
3. Is Palonosetron safe for children?
Yes, certain formulations are approved for pediatric use. Dosing must follow clinical guidelines.
4. What makes Palonosetron different from ondansetron or granisetron?
It has a longer duration of action, higher receptor affinity, and is often more effective in preventing delayed CINV.
 
Looking for a reliable Palonosetron Hydrochloride Injection manufacturer?
Contact Farbe Firma Pvt. Ltd. for complete dossier support, CTD documentation, registration assistance, and global export supplies.