Calcitrol Injection

What is Calcitrol Injectionn?
Calcitriol Injection is the sterile, aqueous form of the active metabolite of Vitamin D3 ($1,25-dihydroxyvitamin D_3$). Unlike standard Vitamin D supplements which require activation by the liver and kidneys, Calcitriol is pre-activated. This makes it an essential medication for patients with severe kidney disease whose bodies can no longer convert Vitamin D into its usable form. By providing the active hormone directly into the bloodstream, it helps maintain healthy calcium and phosphorus levels.
Uses of Calcitriol Injection
Secondary Hyperparathyroidism: To reduce elevated levels of parathyroid hormone (PTH) in patients with moderate to severe chronic kidney disease (CKD).
Hypocalcemia in Dialysis: Management of low blood calcium levels in patients undergoing long-term hemodialysis.
Renal Osteodystrophy: Prevention and treatment of metabolic bone disease in patients with chronic renal failure.
Hypoparathyroidism: Management of hypocalcemia in patients with postsurgical or idiopathic hypoparathyroidism when oral therapy is insufficient.
How Does Calcitriol Injection Work?
Calcitriol works by binding to Vitamin D receptors (VDR) in the intestines, bones, and kidneys. In the intestines, it stimulates the active transport of calcium and phosphorus into the blood. In the parathyroid glands, it directly suppresses the synthesis and secretion of Parathyroid Hormone (PTH). By balancing these minerals, it prevents the body from "stealing" calcium from the bones, thereby protecting bone density and preventing fractures in renal patients.
FAQs on Calcitriol Injection
1. Why is the injection preferred over oral Calcitriol for dialysis patients?
In patients on hemodialysis, the intravenous route ensures 100% bioavailability and bypasses potential absorption issues in the gut. It also allows for more precise control of PTH levels, as the rapid peak in blood concentration is highly effective at "turning off" overactive parathyroid glands.
2. What is the most common side effect to monitor?
The primary risk is Hypercalcemia (excessively high blood calcium). Symptoms can include nausea, vomiting, constipation, and in severe cases, cardiac arrhythmias. Because of this, patients must undergo regular blood tests to monitor calcium, phosphorus, and PTH levels.
3. How is the dose determined?
The dose is highly individualized. It is usually started at a low dose (e.g., 0.5 mcg) administered at the end of each dialysis session and titrated based on the patient's biochemical response. The goal is to lower PTH while keeping calcium and phosphorus within a safe range.
Therapeutic Category
Vitamins & Minerals (Active Vitamin D3 Analog)
Looking for a reliable Calcitriol Injection manufacturer?
Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies. We specialize in high-purity metabolic injectables manufactured in our WHO-GMP certified facility.