Clevidipine Injectable Emulsion

What is Clevidipine Injectable Emulsion?
Clevidipine Injectable Emulsion is a third-generation, ultra-short-acting dihydropyridine calcium channel blocker. It is uniquely formulated as a lipid emulsion for intravenous use. Because of its rapid onset and offset of action, it is a critical tool in critical care and surgical environments where precise, minute-to-minute control of blood pressure is required.
Uses of Clevidipine Injectable Emulsion
Management of acute hypertension when oral therapy is not feasible or desirable.
Control of blood pressure during cardiac surgery (pre-operative, intra-operative, and post-operative).
Treatment of hypertensive emergencies in the Intensive Care Unit (ICU).
Reduction of blood pressure in patients with acute stroke or intracranial hemorrhage where strict BP targets are mandatory.
Rapid stabilization of hemodynamics in patients undergoing vascular procedures.
How Does Clevidipine Injectable Emulsion Work?
Clevidipine works by selectively inhibiting the influx of calcium ions into the vascular smooth muscle cells. This results in the relaxation of the arterial resistance vessels, leading to a decrease in systemic vascular resistance (SVR). Unlike some other antihypertensives, it does not affect venous tone or heart contractility.
FAQs on Clevidipine Injectable Emulsion
1. How fast does Clevidipine start and stop working? Clevidipine has an incredibly fast onset of action, typically working within 2–4 minutes. Its half-life is approximately 1 minute, meaning that once the infusion is stopped, its effects wear off almost immediately (usually within 5–15 minutes), allowing for high "titratability."
2. Are there any dietary restrictions or allergies to consider? Yes. Because Clevidipine is formulated in a lipid emulsion (similar to Propofol), it contains soybean oil and egg phospholipids. Therefore, it is strictly contraindicated in patients with known allergies to soybeans, soy products, eggs, or egg products.
3. Does Clevidipine require a specific administration set? It should be administered via a controlled infusion pump. Because the product is a lipid emulsion, the infusion line must be changed every 12 hours if the vial is breached, to prevent the risk of bacterial contamination or "wicking."
4. How does Clevidipine affect the heart rate? While it is highly selective for blood vessels, a rapid decrease in blood pressure can sometimes cause a reflex tachycardia (increased heart rate). Clinicians usually titrate the dose gradually to achieve the target blood pressure without causing excessive heart rate changes.
Therapeutic Category
Cardiovascular (Antihypertensives / Calcium Channel Blockers)
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