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Eculizumab Injection

Updated: Nov 14, 2023

Eculizumab Injection

Eculizumab is a monoclonal antibody medication used in the treatment of certain rare and serious medical conditions. It works by inhibiting the complement system, a part of the immune system that plays a role in inflammation and the body's defense against pathogens. Eculizumab specifically targets a protein called C5 in the complement system.

Here are some key uses of eculizumab:

  1. Paroxysmal Nocturnal Hemoglobinuria (PNH): Eculizumab is primarily approved for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). PNH is a rare, acquired blood disorder in which red blood cells are destroyed by the complement system, leading to anemia, fatigue, and other complications. Eculizumab helps prevent this destruction by blocking the complement system's activity.

  2. Atypical Hemolytic Uremic Syndrome (aHUS): Eculizumab is also used to treat atypical hemolytic uremic syndrome (aHUS), another rare disorder that can cause kidney failure, anemia, and low platelet levels. It is particularly effective in cases of aHUS associated with uncontrolled activation of the complement system.

  3. Myasthenia Gravis: In some cases, eculizumab has been used off-label to treat myasthenia gravis, an autoimmune neuromuscular disorder. It is thought to work by reducing the destruction of acetylcholine receptors on muscle cells, thereby improving muscle function.

Eculizumab is typically administered intravenously (IV) and requires regular infusions Eculizumab Injection. It is an important treatment option for patients with these rare and potentially life-threatening conditions, but it is also quite expensive and may be associated with certain side effects, including an increased risk of infections. As with any medication, its use should be carefully monitored by healthcare professionals. Patients considering eculizumab should consult with their healthcare provider to determine if it is an appropriate treatment option for their specific condition.


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