Carbetocin Injection

What is Carbetocin Injection?
Carbetocin Injection is a synthetic long-acting analogue of human oxytocin, specifically used in obstetrics.3 It belongs to the class of oxytocic agents and plays a vital role in maternal health by ensuring the uterus contracts effectively after a Cesarean section or vaginal delivery, thereby preventing life-threatening blood loss.4
 
Uses of Carbetocin Injection
Prevention of postpartum hemorrhage (PPH) following Cesarean section under epidural or spinal anesthesia.
Prevention of uterine atony (lack of muscle tone in the uterus) after childbirth.5
 
Management of the third stage of labor in both hospital and clinical settings.
Alternative to conventional oxytocin for long-term uterine contraction stability.6
 
Reduction of the need for additional uterotonic drugs during the postpartum period.7
 
How Does Carbetocin Injection Work?
Carbetocin works by selectively binding to oxytocin receptors in the smooth muscle of the uterus.8 This binding triggers rhythmic uterine contractions, increasing the frequency of existing contractions and raising the tone of the uterine musculature to close off bleeding vessels at the placental site.9
 
FAQs on Carbetocin Injection
1. What is the advantage of Carbetocin over Oxytocin?
Carbetocin has a significantly longer half-life than standard oxytocin.10 While oxytocin may require continuous infusion to maintain uterine tone, a single dose of Carbetocin provides a prolonged effect, reducing the need for additional monitoring and repeat dosing.11
2. Can Carbetocin be used to induce labor?
No, Carbetocin is not indicated for the induction of labor. It is specifically formulated for use after the delivery of the baby to prevent excessive bleeding. It should never be administered before the delivery of the infant.
3. How is Carbetocin Injection administered?
It is typically administered as a single slow intravenous (IV) bolus or intramuscular (IM) injection by a healthcare professional immediately following the delivery of the baby, preferably before the delivery of the placenta in some clinical protocols.12
4. Are there any specific storage requirements for Carbetocin?
While older formulations required constant refrigeration ($2\text{°C}$ to $8\text{°C}$), many modern heat-stable versions are available. However, it is generally recommended to store it in a cool, dark place and protect it from light to ensure maximum potency.
Therapeutic Category
Others (Obstetrics & Gynecology / Uterotonics)
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