Mesna Injection

What is Mesna Injection?
Mesna Injection is a specialized chemoprotective agent used in oncology. It is not an anticancer drug itself, but rather a mandatory supportive medication administered alongside certain chemotherapy drugs like Ifosfamide and high-dose Cyclophosphamide. Mesna acts as a regional detoxifier, specifically protecting the bladder lining from the toxic metabolites produced by these treatments, which would otherwise cause severe internal bleeding.
Uses of Mesna Injection
Hemorrhagic Cystitis Prevention: Primarily used to prevent irritation and bleeding of the bladder during Ifosfamide therapy.
High-Dose Cyclophosphamide Support: Often used as a prophylactic measure when high doses of Cyclophosphamide are required.
Uroprotection: Shields the urinary tract from acrolein, a toxic byproduct of nitrogen mustard-derived chemotherapy.
Oncology Adjunct: Essential in treatment protocols for various cancers, including sarcomas and lymphomas, to ensure patient safety during aggressive treatment.
How Does Mesna Injection Work?
When Ifosfamide or Cyclophosphamide is metabolized in the liver, it produces a toxic substance called acrolein. This toxin is concentrated in the bladder and causes severe inflammation and bleeding (cystitis). Mesna works by traveling to the kidneys and concentrating in the urine. There, its thiol group binds with acrolein to form a stable, non-toxic compound that is safely flushed out of the body.
FAQs on Mesna Injection
1. Is Mesna necessary for every chemotherapy patient? No. Mesna is specifically required for patients receiving Ifosfamide or very high doses of Cyclophosphamide. It is not needed for most other types of chemotherapy.
2. How is Mesna Injection administered? It is typically given via intravenous (IV) injection or infusion. Because it needs to be present in the bladder at the same time as the toxic metabolites, it is often administered as a bolus before chemotherapy, followed by several doses throughout the day, or as a continuous infusion.
3. Does Mesna interfere with the effectiveness of chemotherapy? No. Mesna is a regional detoxifier. It is specifically designed to work only in the urinary tract. It does not enter the tumor cells or interfere with the anticancer action of the drugs; it simply protects the bladder.
Therapeutic Category
Others (Cytotoxic Protector / Uroprotective Agent)
Looking for a reliable Mesna Injection manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies. We provide high-quality oncology support injectables manufactured under strict WHO-GMP compliance.