Nefopam Hydrochloride Injection

What is Nefopam Hydrochloride Injection?
Nefopam Hydrochloride Injection is a unique, non-opioid, non-steroidal centrally acting analgesic. It belongs to the benzoxazocine chemical class. Unlike morphine or fentanyl, it does not cause respiratory depression or have a high potential for addiction, and unlike NSAIDs, it does not interfere with platelet function or irritate the gastric mucosa. This makes it a highly versatile tool in modern multimodal analgesia protocols, particularly for patients who cannot tolerate traditional painkillers.
Uses of Nefopam Hydrochloride Injection
Acute Post-Operative Pain: Management of moderate to severe pain following surgical procedures.
Post-Operative Shivering: Effective prevention and treatment of shivering associated with anesthesia and surgery.
Traumatic Pain: Relief of pain resulting from fractures or soft tissue injuries.
Opioid-Sparing Therapy: Used as an adjunct to reduce the total dose of opioids required, thereby minimizing opioid-related side effects.
Chronic Pain Flares: Management of acute exacerbations of chronic pain conditions when oral therapy is insufficient.
How Does Nefopam Hydrochloride Injection Work?
The mechanism of Nefopam is distinct from other analgesics. It acts primarily in the central nervous system by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. By increasing the concentration of these neurotransmitters in the synaptic cleft, it enhances the body's descending inhibitory pain pathways. Additionally, it appears to modulate sodium and calcium channels, further reducing the transmission of pain signals to the brain.
FAQs on Nefopam Hydrochloride Injection
1. Is Nefopam an opioid or an NSAID? Neither. Nefopam is a centrally acting analgesic that is chemically distinct from both opioids and non-steroidal anti-inflammatory drugs. It provides significant pain relief without the risk of respiratory depression associated with opioids or the gastrointestinal and renal risks associated with NSAIDs.
2. How is it administered? It is typically administered via slow intravenous (IV) infusion or intramuscular (IM) injection. For IV use, it should be infused over 15 to 30 minutes to minimize the risk of side effects like tachycardia or nausea.
3. What are the common side effects? The most frequently reported side effects include sweating (diaphoresis), nausea, dizziness, and a rapid heart rate (tachycardia). Because of its anticholinergic-like effects, it should be used with caution in patients with a history of urinary retention or glaucoma.
Therapeutic Category
Pain & Analgesics (Non-Opioid Analgesic)
Looking for a reliable Nefopam Hydrochloride Injection manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies. We provide high-quality sterile injectables manufactured in our WHO-GMP compliant facility to meet global pharmaceutical standards.