Oxycodone Hydrochloride Injection

What is Oxycodone Hydrochloride Injection?
Oxycodone Hydrochloride Injection is a potent semi-synthetic opioid agonist derived from the poppy alkaloid, thebaine. It is a sterile solution intended for parenteral administration when oral pain medication is either ineffective or not feasible. Known for its high affinity for the central nervous system, it provides robust analgesia for acute, severe pain, making it a staple in post-operative recovery and palliative care.
Uses of Oxycodone Hydrochloride Injection
Acute Post-Operative Pain: Rapid relief of severe pain following major abdominal, orthopedic, or thoracic surgeries.
Cancer Pain Management: Used for "breakthrough" pain in oncology patients who are already on a baseline of oral opioids.
Severe Trauma: Immediate stabilization of pain in patients with significant physical injuries or fractures.
Palliative Care: Providing end-of-life comfort and symptom management for terminal illnesses.
Alternative to Morphine: Often used in patients who experience intolerable side effects (like severe itching or hallucinations) from morphine.
How Does Oxycodone Hydrochloride Injection Work?
Oxycodone acts as a full agonist at the mu-opioid receptors in the brain, spinal cord, and smooth muscles. By binding to these receptors, it inhibits the release of neurotransmitters involved in the transmission of pain (such as substance P) and activates descending inhibitory pathways. This results in an altered perception of pain and an increased pain tolerance. Unlike some other opioids, it also has a significant affinity for kappa-opioid receptors, which may contribute to its unique analgesic profile.
FAQs on Oxycodone Hydrochloride Injection
1. How does Oxycodone compare to Morphine in terms of strength? When administered intravenously, Oxycodone is generally considered to be equipotential or slightly more potent than morphine (ratio of approximately 1:1 or 1:1.5). However, it is often reported to have a lower incidence of histamine release, which means less itching and redness for the patient compared to morphine.
2. How is this medication administered? It can be given via slow intravenous (IV) injection, intravenous infusion, or subcutaneous injection. For IV bolus doses, the injection should be administered slowly over at least 2 to 3 minutes to minimize the risk of respiratory depression and hypotension.
3. What is the risk of dependence? As a Schedule II controlled substance, Oxycodone has a high potential for abuse and dependence. It is intended for short-term acute use or strictly monitored chronic use in specialized settings like oncology or palliative care. Healthcare providers must follow stringent storage and dispensing protocols.
Therapeutic Category
Pain & Analgesics (Opioid Analgesic)
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