Ibuprofen Injection

What is Ibuprofen Injection?
Ibuprofen Injection is a sterile, non-pyrogenic solution of a widely used Non-Steroidal Anti-Inflammatory Drug (NSAID). Unlike oral forms, the injectable version is designed for intravenous (IV) administration, providing rapid onset of action in clinical and hospital settings. It is an essential component of multimodal analgesia, often used to reduce the requirement for opioid painkillers following surgery.
Uses of Ibuprofen Injection
Post-Operative Pain: Management of acute pain immediately following surgical procedures.
Fever Reduction: Rapid reduction of high body temperature when oral antipyretics are not feasible.
Moderate to Severe Pain: Used as an adjunct to opioid analgesics to enhance pain relief.
Rheumatoid & Osteoarthritis: Acute management of inflammatory flares in a hospital setting.
Patent Ductus Arteriosus (PDA): Specifically used in neonates (in specialized formulations) to close a persistent opening in the heart.
How Does Ibuprofen Injection Work?
Ibuprofen works by inhibiting the enzymes Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2). These enzymes are responsible for the synthesis of prostaglandins, which are chemical messengers in the body that signal pain, cause inflammation, and trigger fever in the hypothalamus. By blocking their production, Ibuprofen effectively "turns off" the source of pain and swelling at the site of injury or surgery.
FAQs on Ibuprofen Injection
1. Can Ibuprofen Injection be given directly into the vein? No. Ibuprofen Injection must be diluted before intravenous infusion. It is typically added to a compatible solution like Normal Saline (0.9% NaCl) or Dextrose (D5W) and infused over a period of 5 to 30 minutes, depending on the indication.
2. How does using Ibuprofen Injection help reduce opioid use? When used as part of a "multimodal" approach, Ibuprofen targets inflammation-related pain, allowing doctors to use lower doses of opioids (like morphine or fentanyl). This helps minimize opioid-related side effects such as respiratory depression, nausea, and constipation.
3. Is Ibuprofen Injection safe for patients with kidney issues? Caution is required. Like all NSAIDs, Ibuprofen can affect renal blood flow. It is generally avoided in patients with severe renal impairment or those who are significantly dehydrated to prevent further stress on the kidneys.
Therapeutic Category
Pain & Analgesics (NSAID)
Looking for a reliable Ibuprofen Injection manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies. We provide high-quality, hospital-grade injectables manufactured in our state-of-the-art sterile facility.