Remifentanil Hydrochloride for Injection

What is Remifentanil Hydrochloride?
Remifentanil Hydrochloride is a potent, ultra-short-acting synthetic opioid analgesic. It is unique in the opioid family because of its chemical structure, which contains an ester link. This allows the drug to be rapidly broken down by non-specific blood and tissue enzymes (esterases). Unlike other opioids that depend on the liver or kidneys for clearance, Remifentanil is "organ-independent," providing clinicians with unmatched control over the depth of analgesia.
Uses of Remifentanil Hydrochloride
Induction of Anesthesia: Provides rapid, high-intensity analgesia during the start of surgery to blunt the body's stress response to intubation.
Maintenance of General Anesthesia: Used as part of a Total Intravenous Anesthesia (TIVA) protocol to keep the patient stable during surgical stimulation.
Critical Care Sedation: Used in the ICU for mechanically ventilated patients, allowing for frequent "neurological wake-up tests" due to its rapid offset.
Monitored Anesthesia Care (MAC): Providing potent, short-term pain relief for diagnostic or minor surgical procedures.
Cardiac Surgery: Favored for its predictable profile in patients with complex organ dysfunction.
How Does Remifentanil Work?
Remifentanil is a selective mu-opioid receptor agonist. It binds to receptors in the brain and spinal cord to inhibit pain transmission. Its defining characteristic is its pharmacokinetics: it has a "context-sensitive half-life" of approximately 3 to 4 minutes, regardless of how long the infusion has been running. This means once the infusion is stopped, the drug’s effect disappears almost immediately, allowing the patient to regain natural breathing and consciousness faster than with any other opioid.
FAQs on Remifentanil Hydrochloride
1. Why is Remifentanil called "Organ-Independent"? Because it is metabolized by widespread esterases in the blood and muscle tissue rather than the liver or kidneys. This makes it exceptionally safe for patients with hepatic or renal failure, as the drug will not accumulate in their system.
2. Does Remifentanil require a transition to other painkillers? Yes. Because its effects disappear within minutes of stopping the infusion, clinicians must administer a longer-acting analgesic (such as Morphine or Oxycodone) before the end of surgery. If not, the patient may experience a sudden and intense return of pain upon waking.
3. How is it administered? It is strictly for intravenous (IV) use and must be administered via a calibrated infusion device. Because it is highly potent and fast-acting, it is usually given as a continuous infusion rather than intermittent boluses.
Therapeutic Category
Pain & Analgesics (Ultra-Short-Acting Opioid)
Looking for a reliable Remifentanil Hydrochloride manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies. We provide high-potency, lyophilized sterile injectables manufactured in our WHO-GMP compliant facility to meet global anesthesia standards. Remifentanil Hydrochloride for Injection