Physostigmine Salicylate Injection

What is Baclofen Solution for Injection?
Baclofen Solution for Injection is a sterile, pyrogen-free solution of a GABA-derivative skeletal muscle relaxant. While oral baclofen is common, the injectable form is specifically designed for intrathecal administration—delivered directly into the cerebrospinal fluid (CSF). This route is reserved for patients with severe, chronic spasticity who are unresponsive to oral medications or experience intolerable side effects at therapeutic oral doses.
Uses of Baclofen Solution for Injection
Cerebral Origin Spasticity: Management of severe muscle stiffness and spasms resulting from Cerebral Palsy (CP) or Traumatic Brain Injury (TBI).
Spinal Cord Origin Spasticity: Treatment of spasms associated with Spinal Cord Injury (SCI) or Multiple Sclerosis (MS).
Intrathecal Pump Therapy: Used in long-term management where a programmable pump is surgically implanted to deliver a precise, continuous dose.
Screening Trials: Administered as a single bolus dose via lumbar puncture to determine if a patient is a suitable candidate for a permanent pump implant.
How Does Baclofen Solution for Injection Work?
Baclofen is a GABA-B receptor agonist. It works by mimicking the action of GABA (gamma-aminobutyric acid), the body’s primary inhibitory neurotransmitter. By binding to GABA-B receptors in the dorsal horn of the spinal cord, it inhibits the release of excitatory amino acids (like glutamate and aspartate). This suppresses the overactive "stretch reflexes" that cause muscle tightness, effectively "turning down the volume" on the electrical signals that cause spasms.
FAQs on Baclofen Solution for Injection
1. Why is it injected into the spine rather than a vein? Baclofen crosses the blood-brain barrier poorly when given orally or intravenously. By injecting it intrathecally, the medication reaches the target receptors in the spinal cord directly. This achieves therapeutic levels with a dose roughly 100 times smaller than the oral equivalent, significantly reducing systemic side effects like extreme drowsiness.
2. What are the signs of "Baclofen Withdrawal"? Abrupt discontinuation of intrathecal baclofen is a medical emergency. Symptoms can include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity. It is critical that the delivery system (pump or catheter) is monitored to ensure a continuous supply.
3. How is the dose determined? The dose is highly individualized. It typically begins with a "screening dose" to assess the patient’s clinical response. If successful, a maintenance dose is established using a programmable pump, which can be adjusted by a clinician to balance muscle relaxation with the strength needed for standing or walking.
Therapeutic Category
Skeletal Muscle Relaxant (Centrally Acting)
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