Carboprost Tromethamine Injection

What is Carboprost Injection?
Carboprost Tromethamine Injection is a synthetic analogue of the naturally occurring prostaglandin F2α. It is a potent oxytocic agent used primarily in emergency obstetric care. Its rapid action makes it a critical medication for managing severe bleeding after childbirth and for medical termination of pregnancy in specific clinical scenarios.
Uses of Carboprost Injection
Postpartum Hemorrhage (PPH): Treatment of uterine atony (when the uterus does not contract effectively after birth) that has not responded to conventional methods like oxytocin or uterine massage.
Abortion (Second Trimester): For the termination of pregnancy between the 13th and 20th weeks of gestation.
Incomplete Abortion: To assist in the expulsion of the fetus in cases of missed or incomplete mid-trimester abortions.
Cervical Ripening: Occasionally used to soften and dilate the cervix before surgical procedures.
How Does Carboprost Injection Work?
Carboprost works by stimulating the smooth muscle of the uterus, causing it to undergo strong, rhythmic contractions. In the case of postpartum hemorrhage, these contractions compress the blood vessels within the uterine wall, effectively stopping excessive bleeding. When used for pregnancy termination, the induced contractions lead to the evacuation of the contents of the uterus.
FAQs on Carboprost Injection
1. How is Carboprost Injection administered? It is administered via deep intramuscular (IM) injection. It should never be administered intravenously (IV), as this can cause sudden and severe side effects, including bronchospasm or hypertension.
2. Is this medication safe for patients with asthma? No, Carboprost is generally contraindicated in patients with active pulmonary disease or acute pelvic inflammatory disease. Because it can cause constriction of the airways (bronchospasm), it must be used with extreme caution in patients with a history of asthma.
3. What are the most common side effects? Due to its effect on smooth muscle throughout the body, common side effects include transient diarrhea, nausea, vomiting, and an increase in body temperature (flushing or chills). These are typically manageable with supportive care.
4. How quickly does Carboprost start to work for bleeding? In cases of uterine atony, the effect is often seen very rapidly, typically within a few minutes of the intramuscular injection, helping to stabilize the patient during a postpartum emergency.
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