Cyclizine Lactate Injection

What is Cyclizine Lactate Injection?
Cyclizine Lactate Injection is a potent sedating antihistamine and anticholinergic agent. It belongs to the piperazine derivative class and is primarily used as an antiemetic. It is particularly valued in clinical settings for its ability to treat motion sickness and postoperative nausea where oral administration is not possible. It is a vital tool for managing vertigo and inner-ear related balance disorders.
Uses of Cyclizine Lactate Injection
Postoperative Nausea & Vomiting (PONV): Prevention and treatment of sickness following surgical anesthesia.
Motion Sickness: Rapid relief from nausea and vomiting associated with travel.
Vertigo and Meniere’s Disease: Management of dizziness and spinning sensations caused by inner ear problems.
Radiation Sickness: Control of nausea in patients undergoing radiotherapy.
Drug-Induced Nausea: Management of vomiting caused by certain medications, such as opioids.
How Does Cyclizine Lactate Injection Work?
Cyclizine works by blocking H1 histamine receptors and muscarinic acetylcholine receptors in the vomiting center of the brain and the vestibular apparatus (the balance organ in the inner ear). By inhibiting these signals, it reduces the sensitivity of the labyrinthine apparatus, effectively "quieting" the triggers that lead to nausea, vomiting, and the sensation of spinning.
FAQs on Cyclizine Lactate Injection
1. How is Cyclizine Lactate administered? It is typically administered via intramuscular (IM) injection or slow intravenous (IV) injection. When given intravenously, it should be injected slowly to minimize the risk of a sudden drop in blood pressure or a rapid heart rate.
2. Can Cyclizine be used for morning sickness during pregnancy? While Cyclizine is sometimes used for severe pregnancy-related vomiting (Hyperemesis Gravidarum), it should only be used under strict medical supervision and when other first-line treatments have failed.
3. Does this injection cause drowsiness? Yes, drowsiness is a common side effect of Cyclizine Lactate. Because it crosses the blood-brain barrier, it can also cause dry mouth, blurred vision, and occasional lightheadedness. Patients should be monitored after administration, especially if they need to be mobile.
Therapeutic Category
Gastrointestinal (Antiemetic / Antivertigo)
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