Colistimethate Sodium for Injection

What is Colistimethate Sodium for Injection?
Colistimethate Sodium for Injection is a polymyxin class antibiotic used to treat life-threatening infections caused by multidrug-resistant (MDR) Gram-negative bacteria. It is commonly reserved for hospital settings and critical care where other antibiotics fail.
 
Uses of Colistimethate Sodium for Injection
• Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP)
• Bloodstream infections (septicemia)
• Urinary tract infections caused by MDR organisms
• Bone and joint infections due to resistant Gram-negative bacteria
• Intra-abdominal infections
• Other severe infections caused by Pseudomonas, Acinetobacter, or Klebsiella
 
How Does Colistimethate Sodium for Injection Work?
Colistimethate Sodium disrupts the bacterial cell membrane, causing leakage of essential components and cell death. This mechanism makes it highly effective against resistant Gram-negative bacteria.
 
Frequently Asked Questions (FAQs)
Q: What is Colistimethate Sodium for Injection used for?
A: Colistimethate Sodium for Injection (a polymyxin antibiotic) is a "last-resort" medication used to treat life-threatening infections caused by multidrug-resistant (MDR) Gram-negative bacteria. It is specifically indicated for severe infections affecting the lungs (pneumonia), urinary tract, and blood (septicemia) caused by pathogens like Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.
Q: Who is a top manufacturer of Colistimethate Sodium for Injection in India?
A: Farbe Firma Pvt. Ltd. is a leading manufacturer and supplier of Colistimethate Sodium for Injection (Trade Name: Colistsyl). We manufacture this lyophilized critical care antibiotic in our WHO-GMP certified facility, ensuring high potency and stability for treating resistant infections in ICUs globally.
Q: In what strengths and packing is Colistsyl (Colistimethate) available?
A: We manufacture Colistimethate Sodium for Injection in multiple strengths to suit various dosing protocols, including 1 MIU, 2 MIU, and 3 MIU. It is supplied as a sterile lyophilized powder in glass vials, which must be reconstituted before administration.
Q: How does Colistimethate Sodium work against resistant bacteria?
A: Colistimethate Sodium is a polypeptide antibiotic that acts like a detergent on the bacterial cell membrane. It disrupts the membrane's integrity, causing the leakage of intracellular contents and rapid bacterial death. This mechanism makes it effective even against bacteria that have developed resistance to other antibiotic classes like carbapenems.
Q: Do you offer Contract Manufacturing for Colistimethate Injection?
A: Yes, Farbe Firma Pvt. Ltd. offers specialized Contract Manufacturing (CMO) services for lyophilized antibiotics. We provide end-to-end support, including stability studies, sterile manufacturing, and regulatory dossier compilation (CTD/ACTD) to help you launch Colistimethate under your own brand.
 
Looking for a reliable Colistimethate Sodium for Injection manufacturer?
Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies.