Pipotiazine Palmitate Injection

What is Pipotiazine Injection?
Pipotiazine Injection is a long-acting, depot antipsychotic medication belonging to the piperidine class of phenothiazines. It is specifically formulated as an oily injection to be released slowly into the body over several weeks. This makes it a cornerstone treatment for patients who require consistent maintenance therapy but may struggle with daily oral medication adherence, ensuring stable therapeutic levels in the bloodstream.
Uses of Pipotiazine Injection
Chronic Schizophrenia: Long-term maintenance to prevent relapse and manage hallucinations or delusions.
Schizoaffective Disorder: Management of thought disorders combined with mood swings.
Chronic Psychosis: Treatment of long-standing mental disorders where reality is impaired.
Prevention of Relapse: Used in stabilized patients to ensure they do not experience acute psychotic episodes.
Maintenance Therapy: For patients who are non-compliant with or unresponsive to oral antipsychotics.
How Does Pipotiazine Injection Work?
Pipotiazine works by blocking dopamine receptors (specifically D2 receptors) in various pathways of the brain. Psychotic symptoms are often associated with an overactivity of dopamine; by inhibiting these receptors, the medication helps "calm" the overactive signals, thereby reducing hallucinations, delusions, and disorganized thinking. Its palmitate ester form allows for a slow, sustained release from the muscle into the systemic circulation.
FAQs on Pipotiazine Injection
1. How often is Pipotiazine Injection usually administered? Due to its depot formulation, Pipotiazine Palmitate is typically administered once every 3 to 4 weeks via deep intramuscular injection. This frequency may be adjusted by a specialist based on the patient's clinical response.
2. What is the advantage of using the injection over tablets? The primary advantage is compliance. Because it is long-acting, the patient does not need to remember to take a pill every day, which significantly reduces the risk of symptoms returning due to missed doses. It also provides more stable plasma concentrations.
3. Are there specific storage requirements for this injection? Yes. Since it is an oily solution, it should be stored at room temperature (below 25°C) and protected from light. It should not be refrigerated or frozen, as this can affect the consistency of the oil and the release rate of the drug.
Therapeutic Category
CNS & Neurology (Antipsychotic)
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