Ziprasidone Mesylate for Injection

What is Ziprasidone Mesylate for Injection?
Ziprasidone Mesylate for Injection is a sterile, lyophilized (freeze-dried) powder containing an atypical antipsychotic agent.4 It is specifically designed for intramuscular (IM) use in emergency or clinical settings where rapid stabilization of a patient is required.5 Unlike oral antipsychotics, the injectable form provides a fast onset of action to manage severe behavioral disturbances safely and effectively.
 
Uses of Ziprasidone Mesylate for Injection
Acute treatment of agitation in patients with schizophrenia.6
 
Rapid stabilization of patients exhibiting violent or disruptive behavior related to psychotic disorders.
Management of acute manic or mixed episodes associated with Bipolar I Disorder (as part of a broader treatment plan).7
 
Facilitating the transition to oral maintenance therapy once acute symptoms are controlled.
Reducing the risk of injury to the patient or caregivers during acute psychotic breaks.
How Does Ziprasidone Mesylate Work?
Ziprasidone works through a complex mechanism of receptor antagonism. it primarily blocks Dopamine (8$D_2$) and Serotonin (9$5\text{HT}_{2A}$) receptors in the brain.10 It also acts as an agonist at 11$5\text{HT}_{1A}$ receptors and inhibits the reuptake of norepinephrine and serotonin.12 This multi-receptor approach helps balance neurotransmitters to reduce hallucinations, delusions, and severe agitation.
 
FAQs on Ziprasidone Mesylate for Injection
1. How fast does Ziprasidone Injection work for agitation?
The medication is absorbed rapidly following intramuscular injection. Most patients show a significant reduction in agitation symptoms within 15 to 30 minutes, with peak plasma concentrations typically reached within 60 minutes.13
2. Is Ziprasidone Mesylate for Injection meant for long-term use?
No, the injectable form is intended for short-term, acute management only. Clinical guidelines generally recommend limiting the use of the IM injection to three consecutive days.14 Once the patient is stabilized, they should be transitioned to oral Ziprasidone capsules.
3. What is the most important cardiovascular precaution for this drug?
Ziprasidone is known to cause a dose-related prolongation of the QT interval (a measure of heart rhythm).15 It should be avoided in patients with a history of long QT syndrome, recent heart attack, or uncompensated heart failure.16 Periodic ECG monitoring may be required.
4. How should the lyophilized powder be prepared?
The vial must be reconstituted with Sterile Water for Injection.17 It should be shaken vigorously until the contents are completely dissolved, resulting in a clear, colorless to pale pink solution.18 Once reconstituted, it should be used immediately.
Therapeutic Category
CNS & Neurology (Antipsychotics)
Looking for a reliable Ziprasidone Mesylate for Injection manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies.