Fosaprepitant for Injection

What is Fosaprepitant for Injection?
Fosaprepitant for Injection is an intravenous antiemetic and a prodrug of aprepitant. It belongs to the class of medications known as Substance P/Neurokinin 1 (NK1) receptor antagonists. Specifically designed for cancer patients, it is used as part of a regimen to prevent the debilitating nausea and vomiting often caused by highly or moderately emetogenic chemotherapy treatments.
Uses of Fosaprepitant for Injection
Acute CINV: Prevention of nausea and vomiting occurring within 24 hours of starting chemotherapy.
Delayed CINV: Prevention of nausea and vomiting occurring between 24 and 120 hours after chemotherapy.
Highly Emetogenic Chemotherapy (HEC): Used as a primary preventative measure for drugs like cisplatin.
Moderately Emetogenic Chemotherapy (MEC): To manage symptoms in patients undergoing less intense but still nausea-inducing treatments.
Combination Therapy: Often used in conjunction with a 5-HT3 antagonist (like Ondansetron) and a corticosteroid (like Dexamethasone).
How Does Fosaprepitant for Injection Work?
Fosaprepitant is rapidly converted in the body to aprepitant, which then crosses the blood-brain barrier. It works by selectively blocking the NK1 receptors in the brain’s vomiting center. By preventing Substance P (a neuropeptide that triggers the vomit reflex) from binding to these receptors, the medication effectively shuts down the neurological signals that cause the sensation of nausea and the physical act of vomiting.
FAQs on Fosaprepitant for Injection
1. How is Fosaprepitant for Injection administered? It is administered as a single intravenous (IV) infusion over a period of 20 to 30 minutes. This is usually done approximately 30 minutes before the start of the chemotherapy session on Day 1 of the treatment cycle.
2. Does Fosaprepitant treat existing nausea and vomiting? No. Fosaprepitant is strictly a preventative (prophylactic) medication. It is not designed to treat "breakthrough" nausea that is already occurring. It must be administered before chemotherapy to be effective.
3. Are there any drug interactions to be aware of? Yes. Fosaprepitant can interact with several medications, including certain blood thinners (Warfarin), hormonal contraceptives, and medications metabolized by the CYP3A4 enzyme. It is essential to review the patient's full medication list before administration.
Therapeutic Category
Gastrointestinal (Antiemetic)
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