Remdesivir for Injection

What is Remdesivir for Injection?
Remdesivir for Injection is a broad-spectrum antiviral medication and a nucleotide analogue prodrug. It was the first treatment to receive FDA approval for hospitalized patients with COVID-19. By targeting the viral replication process, it helps reduce the duration of hospital stays and prevents the progression of respiratory distress in patients requiring supplemental oxygen.
Uses of Remdesivir for Injection
COVID-19 Hospitalization: Treatment of adults and pediatric patients (weighing at least 3 kg) who are hospitalized with COVID-19.
Mild-to-Moderate COVID-19: Used for high-risk outpatients to prevent the progression to severe disease or hospitalization.
SARS-CoV-2 Management: Specifically targets the RNA polymerase enzyme of the virus.
Lower Respiratory Tract Support: Helps in reducing recovery time for patients with severe pneumonia caused by viral infection.
Antiviral Prophylaxis: In clinical settings for immunocompromised individuals post-exposure to the virus.
How Does Remdesivir for Injection Work?
Remdesivir acts as an RNA polymerase inhibitor. Once it enters the body, it is metabolized into an active form that mimics the building blocks of the virus's genetic material (RNA). When the virus tries to replicate, it incorporates Remdesivir instead of natural nucleotides, which stops the viral RNA chain elongation. This effectively "jams" the viral machinery, preventing the virus from multiplying.
FAQs on Remdesivir for Injection
1. How is Remdesivir administered to a patient? Remdesivir is administered only through intravenous (IV) infusion by healthcare professionals in a clinical setting. A typical course consists of a loading dose on the first day, followed by daily maintenance doses for 3 to 10 days, depending on the severity of the illness.
2. Is Remdesivir effective against different variants of COVID-19? Yes, because Remdesivir targets the highly conserved viral RNA polymerase (the replication engine) rather than the surface spike proteins, it has maintained its effectiveness against multiple variants of the SARS-CoV-2 virus.
3. What monitoring is required during treatment? Before starting and during treatment, healthcare providers must monitor liver function (ALT/AST levels) and kidney function (eGFR), as the drug can occasionally cause elevated liver enzymes or impact renal clearance.
Therapeutic Category
Anti-Infectives (Antiviral)
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