Aprepitant Emulsion for injection

What is Aprepitant Emulsion for Injection?
Aprepitant Emulsion for Injection is an intravenous, non-prodrug formulation of Aprepitant. Unlike Fosaprepitant (which the body must convert into Aprepitant), this emulsion delivers the active drug directly. It is a Substance P/Neurokinin 1 (NK1) receptor antagonist. This specific emulsion formulation is polysorbate 80-free, which reduces the risk of injection-site reactions and hypersensitivity compared to older synthetic formulations.
Uses of Aprepitant Emulsion for Injection
Highly Emetogenic Chemotherapy (HEC): Prevention of acute and delayed nausea and vomiting, including regimens containing Cisplatin.
Moderately Emetogenic Chemotherapy (MEC): Prevention of symptoms in patients undergoing treatments that have a significant risk of inducing vomiting.
Multi-Day Regimens: Provides extended protection against "delayed" nausea (occurring 24–120 hours post-chemo).
Alternative to Fosaprepitant: Ideal for patients who may have sensitivities to the components found in the prodrug form.
How Does Aprepitant Emulsion Work?
Aprepitant works by crossing the blood-brain barrier and selectively binding to NK1 receptors in the area postrema (the vomiting center) of the brain. It blocks the binding of Substance P, a primary neurotransmitter involved in the emetic (vomiting) reflex. By inhibiting this signal, Aprepitant prevents the brain from triggering the physical sensation of nausea and the act of vomiting.
FAQs on Aprepitant Emulsion for Injection
1. How does the Emulsion form differ from Fosaprepitant? While both eventually deliver Aprepitant to the brain, the Emulsion is the active drug itself, whereas Fosaprepitant is a "prodrug" that requires liver enzymes to convert it. The emulsion formulation used in products like Cinvanti is also specifically designed to be gentle on the veins, as it does not contain certain detergents like polysorbate 80.
2. When is the injection administered? It is administered as a single intravenous (IV) infusion or injection on Day 1 of the chemotherapy cycle. It is usually given over 2 to 30 minutes, approximately 30 minutes prior to the start of chemotherapy.
3. Can it be used with other anti-nausea medications? Yes. For maximum efficacy, it is typically part of a three-drug regimen that includes a 5-HT3 antagonist (like Ondansetron) and a corticosteroid (like Dexamethasone).
Therapeutic Category
Gastrointestinal (Antiemetic)
Looking for a reliable Aprepitant Emulsion manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and export supplies. We specialize in advanced lipid-based and emulsion injectables manufactured in our state-of-the-art sterile facility.