Aprotinin Injection

What is Aprotinin Injection?
Aprotinin Injection is a protease inhibitor used as an antifibrinolytic agent to reduce bleeding during complex surgeries such as cardiac surgery. It works by inhibiting enzymes like plasmin, kallikrein, and trypsin, thereby reducing fibrinolysis and stabilizing blood clots. It has clinical significance in minimizing blood loss, decreasing the need for transfusions, and improving surgical outcomes.
 
Uses of Aprotinin Injection
• Reduction of blood loss during cardiopulmonary bypass surgery
• Prevention of excessive fibrinolysis
• Supportive therapy in major surgical procedures
• Management of coagulopathies associated with surgery
• Adjunct in reducing transfusion requirements
 
How Does Aprotinin Injection Work?
Aprotinin works by inhibiting proteolytic enzymes responsible for fibrin breakdown, including plasmin and kallikrein. By doing so, it stabilizes clots and decreases fibrinolysis, leading to reduced bleeding and transfusion needs during surgery.
 
Frequently Asked Questions (FAQs)
Q: What is Aprotinin Injection used for?
A: Aprotinin Injection is a natural protease inhibitor used as an antifibrinolytic agent. It is primarily indicated to reduce blood loss and the need for blood transfusions in patients undergoing cardiopulmonary bypass (CPB) during heart surgery (such as CABG). It works by inhibiting enzymes that break down blood clots, such as plasmin and kallikrein.
Q: Who is a top manufacturer of Aprotinin Injection in India?
A: Farbe Firma Pvt. Ltd. is a leading manufacturer and supplier of Aprotinin Injection (Trade Name: Aprosyl). We manufacture this critical care hemostatic agent in our WHO-GMP certified facility, ensuring high biological activity and sterility for complex surgical procedures.
Q: In what strengths and packing is Aprosyl (Aprotinin) available?
A: We manufacture Aprotinin Injection in concentrations of 10,000 KIU/ml and 50,000 KIU/ml. It is typically available in 50 ml vials or as a lyophilized powder, designed for the high-dose regimens required in cardiac surgery settings.
Q: How does Aprotinin differ from other antifibrinolytics like Tranexamic Acid?
A: While both reduce bleeding, Aprotinin is a broad-spectrum serine protease inhibitor (inhibiting plasmin, kallikrein, and trypsin), whereas Tranexamic Acid is a synthetic lysine analogue that primarily inhibits plasminogen activation. Aprotinin is often reserved for high-risk cardiac surgeries due to its potent mechanism of action.
Q: Do you offer Contract Manufacturing for Aprotinin Injection?
A: Yes, Farbe Firma Pvt. Ltd. offers specialized Contract Manufacturing (CMO) services for biological injectables like Aprotinin. We provide comprehensive support, including bio-assay testing, sterile filling, and regulatory dossier compilation (CTD/ACTD) for global markets.
 
👉 Looking for a reliable Aprotinin Injection manufacturer? Contact Farbe Firma Pvt. Ltd. for dossier support, registration assistance, and global supply.