Understanding Propofol: A Comprehensive Overview of Its Uses and Safety

Introduction to Propofol

Propofol is a rapid-onset, short-acting intravenous anesthetic. It is primarily used for general anesthesia induction and maintenance, ICU sedation, and procedural sedation. When administered properly by trained healthcare professionals, it provides smooth induction with minimal side effects.

What is Propofol?

Propofol (2,6-diisopropylphenol) is a phenolic compound that serves as an intravenous anesthetic agent. Developed in the 1970s, it has become one of the most widely used anesthetics globally due to its favorable pharmacokinetic profile.

Key Facts About Propofol

• Chemical Name: 2,6-diisopropylphenol

• Onset: 30-60 seconds after IV administration

• Duration: 5-10 minutes after a single bolus dose

• Elimination Half-life: 2-24 hours (context-sensitive)

• Metabolism: Hepatic conjugation and renal excretion

  
  

Clinical Uses of Propofol

1. General Anesthesia

Propofol is extensively used for both induction and maintenance of general anesthesia in surgical procedures. Its rapid onset and offset make it ideal for outpatient procedures.

2. ICU Sedation

In intensive care units, propofol provides controllable sedation for mechanically ventilated patients. This allows for rapid awakening when the drug is discontinued.

3. Procedural Sedation

Propofol is also used for conscious sedation during diagnostic and therapeutic procedures. These include endoscopy, cardioversion, and minor surgical procedures.

Dosage and Administration

Propofol dosing varies based on patient factors and clinical indications:

• Induction: 1.5-2.5 mg/kg IV (healthy adults)

• Maintenance: 4-12 mg/kg/hr continuous infusion

• ICU Sedation: 0.3-4.0 mg/kg/hr (titrated to effect)

• Elderly/ASA III-IV: Reduce dose by 25-50%

  
  

Safety Profile and Contraindications

While generally safe when properly administered, propofol has important safety considerations.

Common Side Effects

• Injection site pain (most common)

• Hypotension and bradycardia

• Respiratory depression

• Apnea (temporary)

  
  

Contraindications

• Allergy to propofol, soy, or egg products

• Severe cardiac or respiratory compromise

• Pregnancy (unless benefits outweigh risks)

  
  

Quality Manufacturing Standards

At Farbe Firma Pvt Ltd, we manufacture propofol injection under strict WHO-GMP guidelines. This ensures:

• Sterile manufacturing environment

• Rigorous quality control testing

• Consistent potency and purity

• Proper cold chain storage and handling

  
  

The Importance of Proper Administration

The administration of propofol should only be performed by trained healthcare professionals. This is crucial to ensure patient safety and effective sedation. Monitoring vital signs, oxygen saturation, ECG, and blood pressure is essential during administration.

Frequently Asked Questions

Q: How quickly does propofol work?

A: Propofol typically takes effect within 30-60 seconds of intravenous administration. This rapid onset makes it one of the fastest-acting anesthetic agents available.

Q: Is propofol safe for outpatient procedures?

A: Yes, propofol's rapid recovery profile makes it excellent for outpatient procedures. Patients typically recover quickly with minimal residual effects.

Q: What monitoring is required during propofol administration?

A: Continuous monitoring of vital signs, oxygen saturation, ECG, and blood pressure is essential. Trained anesthesia providers should always administer propofol.

Conclusion

In conclusion, propofol is a vital anesthetic agent in modern medicine. Its rapid onset and short duration make it suitable for various clinical settings. Understanding its uses, safety profile, and proper administration is essential for healthcare professionals.

For more information about propofol and its applications, please refer to the current prescribing information.

Last Updated: September 2025 | Expert Review: Dr. Anesthesiology Team, Farbe Firma Pvt Ltd